APC Mouse Anti-human CD3 Antibody（OKT3）
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产品概述:
产品名称：APC Mouse Anti-human CD3 Antibody（OKT3）
抗体类型：Monoclonal
验证应用：FC
宿主：Mouse
种属反应性：Human
偶联物：APC
克隆号：OKT3
激发光/发射光：651 /660
亚型：Mouse IgG2a, κ产品背景:
The OKT3 monoclonal antibody specifically recognizes the CD3 epsilon subunit (CD3e/CD3ε) of the CD3
complex which consists of four transmembrane proteins (γ, δ, ε, ζ) that are associated with the T cell antigen
receptor (TCR) to form the CD3/TCR complex. The CD3 complex associates with either TCR αβ or TCR γδ
heterodimers that are alternatively expressed by some thymocytes, T cells or NKT cells. The CD3 complex is
required for the cell surface expression and signal-transducing functions of the TCR. The CD3 complex is
expressed by ~60-85% thymocytes and by all peripheral mature T cells. CD3e is also known as T3E or
TCRE. CD3e is a ~20 kDa unglycosylated type I transmembrane protein that is encoded by CD3E which
belongs to the immunoglobulin superfamily (IgSF). CD3e has an Ig-like extracellular domain (ECD) and an
immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.
The OKT3 antibody can reportedly fix complement, stimulate T cell proliferation and cytokine production,
and block the binding of other human CD3e-specific antibodies including UCHT1 and SK7.
Other Names: T3, CD3ε
Gene ID: 916
Excitation Laser: Red laser (633 nm)结果示例：
Fig.1. APC Mouse Anti-human CD3 Antibody染色人PBMC效果图，5µL/test.
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产品组成：
货号/规格 组分名称 体积 16-1003-12 25T APC Mouse Anti-human CD3 Antibody（OKT3） 125 μL 16-1003-15 100T APC Mouse Anti-human CD3 Antibody（OKT3） 500 μL 保存：2-8℃避光保存。冰袋运输。
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