PE/Cyanine7 Mouse Anti-human CD8a Antibody（OKT8）
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- 产品描述
- 组成成分
- 注意事项
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产品概述:
产品名称：PE-Cy7 Mouse Anti-human CD8a Antibody（OKT8）
抗体类型：Monoclonal
验证应用：FC
宿主：Mouse
种属反应性：Human
偶联物：PE-Cy7
克隆号：OKT8
激发光/发射光：565/778
亚型：Mouse IgG2a产品背景:
The OKT8 monoclonal antibody specifically recognizes CD8 alpha (CD8a or CD8α). CD8a is a ~32-34 kDa
type I transmembrane glycoprotein that is encoded by CD8A, which belongs to the immunoglobulin
superfamily (IgSF), and is commonly referred to as CD8.
CD8a is expressed by the majority of thymocytes, subpopulations of αβ T cells and γδ T cells, and by subsets
of NK cells. Cell surface CD8a is expressed either as a disulfide-linked homodimer (CD8αα) or as a
heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8b or CD8β). CD8-positive αβ T cells
coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express
CD8αα homodimers.
CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to
a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a
coreceptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of
CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The
OKT8 antibody reportedly crossreacts with CD8a expressed by leucocytes from some non-human primate
(NHP) species.
PE-Cy7 can be excited by the Blue (488-nm), Green (532-nm) and yellow-green (561-nm) lasers.结果示例：
如图所示：PE-Cy7 Mouse Anti-human CD8 Antibody染色人PBMC效果图，5µL/test
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产品组成：
货号/规格 组分名称 体积 15-1008-12 25T PE-Cy7 Mouse Anti-human CD8a Antibody (OKT8) 125 μL 15-1008-15 100T PE-Cy7 Mouse Anti-human CD8a Antibody (OKT8) 500 μL 保存：2-8℃避光保存。冰袋运输。
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